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Search Results for " tryptophan hydroxylase "

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Cat. No.	Product Name	Target	Signaling Pathways
T7694	6-fluoro-DL-Tryptophan	5-HT Receptor	GPCR/G Protein; Neuroscience
	6-fluoro-DL-Tryptophan 是血清素 (5-HT) 合成的抑制剂。
T21506	Telotristat	Hydroxylase	Metabolism
	Telotristat 是色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂，在体内的IC50值为0.028 μM。
T15796	LX-1031	Hydroxylase; LPA Receptor	GPCR/G Protein; Metabolism
	LX-1031 是一种有效的色氨酸 5-羟化酶抑制剂。 LX-1031 减少外周5-羟色胺的合成。
T14119	ACT-678689 Compound Example 1.53.4	Hydroxylase	Metabolism
	ACT-678689 (Compound Example 1.53.4) 是一种色氨酸羟化酶 (TPH) 抑制剂，IC50=8 nM。
T11897	Telotristat ethyl LX1606	Hydroxylase	Metabolism
	Telotristat ethyl (LX1606) 是一种口服具有活力的色氨酸羟化酶抑制剂，可抑制血清素的产生。
T10142L	p-Ethynylphenylalanine hydrochloride 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)	Hydroxylase	Metabolism
	p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其Ki=32.6 μM。
T6044	Telotristat Etiprate LX1606 (Hippurate),LX 1606 Hippurate,特罗司他马尿酸盐	Hydroxylase	Metabolism
	Telotristat Etiprate (LX 1606 Hippurate) 是一种色氨酸羟化酶抑制剂，可抑制血清素的产生。
T1447	Fenclonine Fenchlonine,PCPA,CP-10188,芬克洛宁,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine	Hydroxylase	Metabolism
	Fenclonine (CP-10188) 是一种有效的色氨酸羟化酶(Trp)的不可逆抑制剂。其中色氨酸羟化酶是 5-羟色胺生物合成的限速酶。
T41143	pCPA methyl ester hydrochloride 4-氯-DL-苯基丙氨酸甲酯盐酸盐,4-Chloro-DL-phenylalanine methyl ester hydrochloride	5-HT Receptor; Hydroxylase	GPCR/G Protein; Metabolism; Neuroscience
	pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是色氨酸羟化酶抑制剂和5-HT 合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。
T15779	LP-533401 hydrochloride	Hydroxylase	Metabolism
	LP-533401 hydrochloride is an inhibitor of tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
T10142	p-Ethynylphenylalanine 4-Ethynyl-L-phenylalanine	Others; Hydroxylase	Metabolism; Others
	p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种色氨酸羟化酶(TPH)抑制剂，具有竞争性、有效性、选择性和可逆性，Ki 为32.6 μM。
T16780	Rodatristat KAR5417	Others	Others
	Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).
T26258	Telotristat besilate
	Telotristat besilate is an inhibitor of tryptophan hydroxylase.
T15778	LP-533401	Hydroxylase	Metabolism
	LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
T69135	AGN-2979
	AGN-2979 is a tryptophan hydroxylase (TPH) activation inhibitor that shows antidepressant properties in rodent models of depression.
T71888	Fenclonine hydrochloride
	Fenclonine hydrochloride is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.
T16779	Rodatristat ethyl RVT-014,KAR5585,RVT-1201	5-HT Receptor; Hydroxylase	GPCR/G Protein; Metabolism; Neuroscience
	Rodatristat ethyl (KAR5585) 是一种首新型具有口服活性和有效性的 tryptophan hydroxylase 1 (TPH1) 抑制剂，低浓度下可显著降低 5-hydroxytryptamine (5-HT) 的水平并降低肺动脉高压 (PAH)，
T78228	4-Chloro-L-phenylalanine L-4-Chlorophenylalanine,L-PCPA	5-HT Receptor	GPCR/G Protein; Neuroscience
	4-Chloro-L-phenylalanine (L-PCPA) 是一种 5-HT 生物合成抑制剂。4-Chloro-L-phenylalanine 也是色氨酸羟化酶(TPH1 和 TPH2)的非特异性拮抗剂。
T79712	TPH1-IN-1
	TPH1-IN-1（compound 40），一种黄嘌呤衍生物，作为色氨酸羟化酶TPH1的抑制剂，显示出110.1 nM的IC50值。该化合物展现了优异的体外活性以及在肝微粒体中的稳定性，并且能有效抑制T3-L1细胞的脂肪细胞分化。

化合物

6-fluoro-DL-Tryptophan

Cat.No: T7694

Target: 5-HT Receptor

Cat.No: T21506

Target: Hydroxylase

Cat.No: T15796

Target: Hydroxylase, LPA Receptor

Cat.No: T14119

Synonym: Compound Example 1.53.4

Target: Hydroxylase

Telotristat ethyl

Cat.No: T11897

Synonym: LX1606

Target: Hydroxylase

p-Ethynylphenylalanine hydrochloride

Cat.No: T10142L

Synonym: 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)

Target: Hydroxylase

Telotristat Etiprate

Cat.No: T6044

Synonym: LX1606 (Hippurate),LX 1606 Hippurate,特罗司他马尿酸盐

Target: Hydroxylase

Cat.No: T1447

Synonym: Fenchlonine,PCPA,CP-10188,芬克洛宁,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine

Target: Hydroxylase

pCPA methyl ester hydrochloride

Cat.No: T41143

Synonym: 4-氯-DL-苯基丙氨酸甲酯盐酸盐,4-Chloro-DL-phenylalanine methyl ester hydrochloride

Target: 5-HT Receptor, Hydroxylase

LP-533401 hydrochloride

Cat.No: T15779

Target: Hydroxylase

p-Ethynylphenylalanine

Cat.No: T10142

Synonym: 4-Ethynyl-L-phenylalanine

Target: Others, Hydroxylase

Cat.No: T16780

Synonym: KAR5417

Target: Others

Telotristat besilate

Cat.No: T26258

Cat.No: T15778

Target: Hydroxylase

Cat.No: T69135

Fenclonine hydrochloride

Cat.No: T71888

Rodatristat ethyl

Cat.No: T16779

Synonym: RVT-014,KAR5585,RVT-1201

Target: 5-HT Receptor, Hydroxylase

4-Chloro-L-phenylalanine

Cat.No: T78228

Synonym: L-4-Chlorophenylalanine,L-PCPA

Target: 5-HT Receptor

Cat.No: T79712

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